Acute Pain
Volume 11, Issue 2 , Pages 43-50 , June 2009

Analgesic effectiveness of flurbiprofen axetil after uterine curettage on abortion: A randomized controlled trial

  • FuZhou Wang

      Affiliations

    • Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 25 84460777 3301; fax: +86 25 84200723.
    • ,
  • XiaoFeng Shen

      Affiliations

    • Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
    • ,
  • XiRong Guo

      Affiliations

    • Institute of Pediatrics, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
    • ,
  • ShiQin Xu

      Affiliations

    • Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
    • ,
  • LiangLiang He

      Affiliations

    • Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
    • ,
  • YuSheng Liu

      Affiliations

    • Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China

Received 13 November 2008 ,Revised 30 January 2009 ,Accepted 2 February 2009.

References 

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  2. Titapant V, Chawanpaiboon S, Boonpektrakul K. Double-blind randomized comparison of xylocaine and saline in paracervical block for diagnostic fractional curettage. J Med Assoc Thai. 2003;86:131–135
  3. Niinimäki M, Jouppila P, Martikainen H, Talvensaari-Mattila A. A randomized study comparing efficacy and patient satisfaction in medical or surgical treatment of miscarriage. Fertil Steril. 2006;86:367–372
  4. Seitsonen ER, Cohen-Laroque ES, van Gils MJ, Korttila KT, Neuvonen PJ, Yli-Hankala AM. Propofol versus alfentanil to prevent movement responses during uterine curettage. Acta Anaesthesiol Scand. 2007;51:751–758
  5. Uerpairojkit K, Urusopone P, Somboonviboon W. A randomized controlled study of three targets of propofol plasma concentration in patients undergoing uterine dilation and curettage. J Obstet Gynaecol Res. 2003;29:79–83
  6. Manyou B, Phupong V. Prospective randomized, double-blinded, placebo-controlled trial of preoperative etoricoxib for pain relief in uterine fractional curettage under paracervical block. Eur J Obstet Gynecol Reprod Biol. 2008;140:90–94
  7. Poomtavorn Y, Phupong V. Prospective randomized, double-blinded, placebo-controlled trial of preoperative rofecoxib for pain relief in uterine curettage. Arch Gynecol Obstet. 2005;273:115–118
  8. Wang F, Shen X, Xu S, Ma L, Liu Y, Feng S, et al. Preemptive combined preventive delivery of flurbiprofen axetil produced effective analgesia after lumpectomy. Acute Pain. 2008;10:65–71
  9. Yamashita K, Fukusaki M, Ando Y, Fujinaga A, Tanabe T, Terao Y, et al. Preoperative administration of intravenous flurbiprofen axetil reduces postoperative pain for spinal fusion surgery. J Anesth. 2006;20:92–95
  10. Mikawa K, Nishina K, Maekawa N, Shiga M, Obara H. Dose-response of flurbiprofen on postoperative pain and emesis after paediatric strabismus surgery. Can J Anaesth. 1997;44:95–98
  11. Buritova J, Besson JM. Peripheral and/or central effects of racemic- S(+)- and R(-)-flurbiprofen on inflammatory nociceptive processes: a c-Fos protein study in the rat spinal cord. Brit J Pharmacol. 1998;125:87–101
  12. Takada M, Fukusaki M, Terao Y, Yamashita K, Inadomi C, Takada M, et al. Preadministration of flurbiprofen suppresses prostaglandin production and postoperative pain in orthopedic patients undergoing tourniquet inflation. J Clin Anesth. 2007;19:97–100
  13. Weinbroum AA, Bender B, Nirkin A, Chazan S, Meller I, Kollender Y. Dextromethorphan-associated epidural patient-controlled analgesia provides better pain- and analgesics-sparing effects than dextromethorphan-associated intravenous patient-controlled analgesia after bone-malignancy resection: a randomized, placebo-controlled, double-blinded study. Anesth Analg. 2004;98:714–722
  14. Olson D, Lynn M, Thoyre SM, Graffagnino C. The limited reliability of the Ramsay scale. Neurocrit Care. 2007;7:227–231
  15. Simon , Benita . Submicron emulsions in drug targeting and delivery. CRC Press; 1998;p. 135
  16. Dilation and curettage-D&C. http://www.netdoctor.co.uk/health_advice/facts/curettage.htm [Last accessed date: August 9, 2008].
  17. Basselin M, Villacreses NE, Lee HJ, Bell JM, Rapoport SI. Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. Neurochem Res. 2007;32:1857–1867
  18. Bolla M, You D, Loufrani L, Levy BI, Levy-Toledano S, Habib A, et al. Cyclooxygenase involvement in thromboxanedependent contraction in rat mesenteric resistance arteries. Hypertension. 2004;43:1264–1269
  19. Van Ryan-McKenna J, Buchanan MR. Relative effects of flurbiprofen on platelet 12-hydroxy-eicosatetraenoic acid and thromboxane A2 production: influence on collagen-induced platelet aggregation and adhesion. Prostaglandins Leukot Essent Fatty Acids. 1989;36:171–174
  20. Nakayama M, Ichinose H, Yamamoto S, Nakabayashi K, Satoh O, Namiki A. Perioperative intravenous flurbiprofen reduces postoperative pain after abdominal hysterectomy. Can J Anaesth. 2001;48:234–237

☆ ClinicalTrials.gov ID: NCT 00725218.

PII: S1366-0071(09)00003-5

doi: 10.1016/j.acpain.2009.02.001

Acute Pain
Volume 11, Issue 2 , Pages 43-50 , June 2009

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