Analgesic effectiveness of flurbiprofen axetil after uterine curettage on abortion: A randomized controlled trial

Wang, FuZhou; Shen, XiaoFeng; Guo, XiRong; Xu, ShiQin; He, LiangLiang; Liu, YuSheng

doi:10.1016/j.acpain.2009.02.001

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Volume 11, Issue 2 , Pages 43-50, June 2009

Analgesic effectiveness of flurbiprofen axetil after uterine curettage on abortion: A randomized controlled trial☆

FuZhou Wang
- Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
- Corresponding author. Tel.: +86 25 84460777 3301; fax: +86 25 84200723.
XiaoFeng Shen
- Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
XiRong Guo
- Institute of Pediatrics, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
ShiQin Xu
- Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
LiangLiang He
- Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China
YuSheng Liu
- Department of Anesthesiology, Affiliated NanJing Maternal and Child Health Care Hospital, NanJing Medical University, No. 123, TianFei Xiang, MoChou Road, NanJing 210004, China

Received 13 November 2008; received in revised form 30 January 2009; accepted 2 February 2009.

Summary

Background

Pain after uterine curettage has not been clearly evaluated. This study was designed to investigate the hypothesis that flurbiprofen axetil used prior to curettage on abortion could decrease 50% pain from uterine contraction.

Methods

Ninety seven ASA physical status I–II patients, undergoing elective uterine apoxesis, were allocated to this randomized double-blind controlled study and assigned into one of two groups (n=45). In the flurbiprofen group, patients received an i.v. injection of flurbiprofen 50mg in 5ml 10min prior to propofol anesthesia. The control group received the same volume of saline injection. Morphine 0.04mg/kg was used as the rescue drug for uncontrolled pain. Visual analog scale for analgesia at rest, satisfaction with analgesia, morphine consumption and side effects were recorded.

Results

A total of 87 patients completed the study. The intention-to-treat number of patients was 45 in each group. Flurbiprofen group evidenced effective analgesia (vs. saline P=0.019), with better satisfaction (P=0.015), lower incidence of nausea, dizziness and drowsiness, pruritus, dry mouth and uterine bleeding than the saline control. The flurbiprofen group consumed less morphine in 1h 0.6mg (interquartile 0.1–1.2), vs. saline group 3.7mg (interquartile 1.5–4.6) (P=0.049). The number of patients needed to treat was 2 in the flurbiprofen group.