Acute Pain
Volume 10, Issue 2 , Pages 93-95 , June 2008

Downbeat nystagmus related with epidural opioid side effect

  • Gema Ruíz

      Affiliations

    • Department of Anaesthesiology, Hospital Universitario Doce de Octubre, Madrid, Spain
    • Corresponding Author InformationCorresponding author at: Hospital Universitario Doce de Octubre, Department of Anaesthesiology, Avda. Andalucía s/n, Km:5.4, CP: 28041 Madrid, Spain. Tel.: +34 91 390 82 43; fax: +34 91 390 80 18.
    • ,
  • Alejandro Orts

      Affiliations

    • Department of Anaesthesiology, Hospital Universitario Doce de Octubre, Madrid, Spain
    • ,
  • Juan Monsalve

      Affiliations

    • Department of Ophthalmology, Hospital Virgen de la Concha, Zamora, Spain
    • ,
  • Pilar Aliste

      Affiliations

    • Department of Anaesthesiology, Hospital Universitario Doce de Octubre, Madrid, Spain
    • ,
  • Adam Ross

      Affiliations

    • Bristol Eye Hospital, Bristol, UK
    • ,
  • Blanca Monsalve

      Affiliations

    • Bristol Eye Hospital, Bristol, UK

Received 17 October 2007 ,Revised 27 February 2008 ,Accepted 7 March 2008.

References 

  1. Leigh RJ, Zee DS. The neurology of eye movements. 3rd ed.. New York: Oxford University Press; 1999;pp. 415–424
  2. Korff C, Peter M, Burkhard PR. Downbeat nystagmus as a manifestation of intrathecal morphine toxicity. Eur J Anaesthesiol. 2006;1–2
  3. Yee R. Downbeat nystagmus: characteristics and localization of lesions. Trend Am Ophthalmol Soc. 1989;LXXXVII:985–1032
  4. Fish DJ, Rosen SM. Epidural opioids as a cause of vertical nystagmus. Anaesthesiology. 1990;73:785–786
  5. Stenvens RA, Sharrock NE. Nystagmus following epidural morphine. Anesthesiology. 1991;74:390–391
  6. Uyeama H, Nishimura M, Tashiro C. Naloxone reversal of nystagmus associated with intrathecal morphine administration. Anaesthesiology. 1992;76:153
  7. Henderson RD, Wijdicks EF. Downbeat nystagmus associated with intravenous patient-controlled administration of morphine. Anesth Analg. 2000;9:691–692
  8. Rottach KG, Wohlgemuth WA, Dzaja AE, Eggert T, Straube A. Effects of intravenous opioids on eye movements in humans: possible mechanisms. J Neurol. 2002;249:1200–1205
  9. Schadrack J, Willoch F, Platzer S, Bartenstein P, Mahal B, Dworzak D, et al. Opioid receptors in the human cerebellum: evidence from (11C)-diprenorphine PET, mRNA expression and autoradiography. Neuroreport. 1999;10:619–624
  10. Wilder S. Opioid use in the elderly. Eur J Pain. 2005;9(2):137–140

PII: S1366-0071(08)00046-6

doi: 10.1016/j.acpain.2008.03.001

Acute Pain
Volume 10, Issue 2 , Pages 93-95 , June 2008

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