Acute Pain
Volume 8, Issue 3 , Pages 109-116 , October 2006

Population pharmacokinetic modelling of subcutaneous morphine in the elderly

  • R.N. Upton

      Affiliations

    • Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital and University of Adelaide, North Terrace, Adelaide, SA 5000, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 8 8303 6382; fax: +61 8 8303 3909.
    • ,
  • T.J. Semple

      Affiliations

    • Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital and University of Adelaide, North Terrace, Adelaide, SA 5000, Australia
    • ,
  • P.E. Macintyre

      Affiliations

    • Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital and University of Adelaide, North Terrace, Adelaide, SA 5000, Australia
    • ,
  • D.J.R. Foster

      Affiliations

    • School of Pharmacy, University of South Australia, Adelaide, SA 5000, Australia

Received 31 March 2006 ,Revised 24 May 2006 ,Accepted 19 June 2006.

References 

  1. Semple TJ, Upton RN, Macintyre PE, Runciman WB, Mather LE. Morphine blood concentrations in elderly postoperative patients following administration via an indwelling subcutaneous cannula. Anaesthesia. 1997;52(4):318–323
  2. McLean CF, Mather LE, Odontiadis J, Sloan PA. Improved method for morphine determination in biological fluids and tissues: rapid, sensitive and selective. J Pharm Pharmacol. 1990;42:669–671
  3. Karlsson MO, Sheiner LB. The importance of modeling interoccasion variability in population pharmacokinetic analyses. J Pharmacokinet Biopharm. 1993;21(6):735–750
  4. R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing; 2005.
  5. Roberts MS, Lipschitz S, Campbell AJ, Wanwimolruk S, McQueen EG, McQueen M. Modeling of subcutaneous absorption kinetics of infusion solutions in the elderly using technetium. J Pharmacokinet Biopharm. 1997;25:1–21
  6. Supersaxo A, Hein WR, Steffen H. Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration. Pharm Res. 1990;7(2):167–169
  7. Charkoudian N. Skin blood flow in adult human thermoregulation: how it works, when it does not, and why. Mayo Clin Proc. 2003;78:603–612
  8. Heistad DD, Abboud FM. Factors that influence blood flow in skeletal muscle and skin. Anesthesiology. 1974;41:139–156
  9. Macintyre PE, Ready LB. Acute pain management—a practical guide. 2nd ed.. London: W.B. Saunders; 2001;
  10. Penson RT, Joel SP, Roberts M, Gloyne A, Beckwith S, Slevin ML. The bioavailability and pharmacokinetics of subcutaneous, nebulized and oral morphine-6-glucuronide. Br J Clin Pharmacol. 2002;53:347–354
  11. Lötsch J, Skarke C, Schmidt H, Liefhold J, Geisslinge G. Pharmacokinetic modeling to predict morphine and morphine-6-glucuronide plasma concentrations in healthy young volunteers. Clin Pharmacol Ther. 2002;72:151–162
  12. Upton RN. The two-compartment recirculatory model—an introduction to recirculatory pharmacokinetic concepts. Br J Anaesth. 2004;92(4):475–484

PII: S1366-0071(06)00038-6

doi: 10.1016/j.acpain.2006.06.002

Acute Pain
Volume 8, Issue 3 , Pages 109-116 , October 2006

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