Acute Pain
Volume 7, Issue 1 , Pages 37-40, May 2005

Effects of succinylcholine on spinal antinociception with lidocaine in rats

  • Weian Zeng

      Affiliations

    • Department of Anesthesiology, Tumor Hospital, Cancer Center, Sun Yat-sen University, 651 Dong Feng Road East, Guangzhou City, Guangzhou 510060, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 20 87343060; fax: +86 20 87343392.
    • ,
  • Haichun Ma

      Affiliations

    • Department of Anesthesiology, The First Hospital of Jilin University, Changchun, China
    • ,
  • Hongying Tan

      Affiliations

    • Department of Anesthesiology, Tumor Hospital, Cancer Center, Sun Yat-sen University, Guangzhou, China
    • ,
  • Shuji Dohi

      Affiliations

    • Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine, Gifu City, Japan

Received 22 March 2004; received in revised form 5 January 2005; accepted 17 January 2005.

Summary 

Aim:

In this study we investigated the antinociceptive effect of intrathecally administered succinylcholine, a muscle relaxant, and examine its potential interaction with lidocaine.

Methods:

Using rats chronically implanted with lumbar intrathecal catheters, the ability of intrathecal succinylcholine and lidocaine, and the mixtures of succinylcholine–lidocaine to alter tail-flick latency was examined. Motor function was assessed using a modified Langerman's scale.

Results:

Intrathecal lidocaine (25–300μg) alone showed the prolongation of tail-flick latency in a time- and dose-dependent manner. Although intrathecal succinylcholine (50 and 100μg) alone demonstrated neither sensory nor motor block, the combination of lidocaine (100 or 200μg) and succinylcholine (100μg) significantly increased the tail-flick threshold. The combination of succinylcholine (100μg) and lidocaine (200μg) did not affect motor function when compared with lidocaine alone.

Conclusion:

These results indicated that the intrathecal succinylcholine potentiates spinal anesthesia with lidocaine.

Keywords: Acetylcholine, Local anesthetics, Spinal analgesia

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PII: S1366-0071(05)00004-5

doi:10.1016/j.acpain.2005.01.003

Acute Pain
Volume 7, Issue 1 , Pages 37-40, May 2005

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